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Article

A general theory of sexual differentiation.

Journal of neuroscience research - 2 Jan 2017

Arnold Arthur P

Abstract excerpt

A general theory of mammalian sexual differentiation is proposed. All biological sex differences are the result of the inequality in effects of the sex chromosomes, which are the only factors that differ in XX vs. XY zygotes. This inequality leads to male-specific effects of the Y chromosome, including expression of the testis-determining gene Sry that causes differentiation of testes. Thus, Sry sets up lifelong...

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Identifiers

PMID: 27870435
DOI: 10.1002/jnr.23884
PMCID: PMC5369239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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