Article
Pathoadaptive Mutations of Escherichia coli K1 in Experimental Neonatal Systemic Infection.
PloS one - 1 Jan 2016
McCarthy Alex J, Negus David, Martin Patricia, Pechincha Catarina, Oswald Eric, Stabler Richard A, Taylor Peter W
Abstract excerpt
Although Escherichia coli K1 strains are benign commensals in adults, their acquisition at birth by the newborn may result in life-threatening systemic infections, most commonly sepsis and meningitis. Key features of these infections, including stable gastrointestinal (GI) colonization and age-dependent invasion of the bloodstream, can be replicated in the neonatal rat. We previously increased the capacity of a...
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