Article
Familial early onset frontotemporal dementia caused by a novel S356T MAPT mutation, initially diagnosed as schizophrenia.
Clinical neurology and neurosurgery - 1 Dec 2010
Momeni Parastoo, Wickremaratchi Mirdhu M, Bell Jason, Arnold Richard, Beer Roger, Hardy John, Revesz Tamas, Neal James W, Morris Huw R
Abstract excerpt
Autosomal dominant frontotemporal dementia (FTD) due to mutations in the MAPT gene is referred to as FTD with parkinsonism linked to chromosome 17 with tau pathology (FTDP-17T). Typically the disease begins in the sixth decade of life. We report a novel exon 12 mutation in MAPT (S356T), in a family with an exceptionally early age at onset (27 and 29 years), causing familial behavioural variant frontotemporal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.