Article
Dwarfism with joint laxity in Friesian horses is associated with a splice site mutation in B4GALT7.
BMC genomics - 28 Oct 2016
Leegwater Peter A, Vos-Loohuis Manon, Ducro Bart J, Boegheim Iris J, van Steenbeek Frank G, Nijman Isaac J, Monroe Glen R, Bastiaansen John W M, Dibbits Bert W, van de Goor Leanne H, Hellinga Ids, Back Willem, Schurink Anouk
Abstract excerpt
BACKGROUND: Inbreeding and population bottlenecks in the ancestry of Friesian horses has led to health issues such as dwarfism. The limbs of dwarfs are short and the ribs are protruding inwards at the costochondral junction, while the head and back appear normal. A striking feature of the condition is the flexor tendon laxity that leads to hyperextension of the fetlock joints. The growth plates of dwarfs display...
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