Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The long and winding road to IgA deficiency: causes and consequences.

Expert review of clinical immunology - 1 Apr 2017

Vo Ngoc D T Laura, Krist Lizette, van Overveld Frans J, Rijkers Ger T

Abstract excerpt

INTRODUCTION: The most common humoral immunodeficiency is IgA deficiency. One of the first papers addressing the cellular and molecular mechanisms underlying IgA deficiency indicated that immature IgA-positive B-lymphocytes are present in these patients. This suggests that the genetic background for IgA is still intact and that class switching can take place. At this moment, it cannot be ruled out that genetic as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Cell Activating Factor
Share to IgA Deficiency
Share to Immunity, Mucosal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin A

Share to Immunoglobulin Class Switching

Share to Microbiota

Share to Precursor Cells, B-Lymphoid

Share to Transmembrane Activator and CAML Interactor Protein

Source

Identifiers

PMID: 27776452
DOI: 10.1080/1744666X.2017.1248410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The long and winding road to IgA deficiency: causes and consequences.PMID 27776452Read ↗

Innate Mechanisms in Selective IgA DeficiencySemantic proximity Read ↗

An overview of early genetic predictors of IgA deficiency.Semantic proximity Read ↗

Selective IgA Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management.Semantic proximity Read ↗

IgA deficiency: what is new?Semantic proximity Read ↗

Immunoglobulin A, an Active Liaison for Host-Microbiota HomeostasisSemantic proximity Read ↗

IgA in human health and diseases: Potential regulator of commensal microbiotaSemantic proximity Read ↗

[Clinical phenotypes associated with selective IgA deficiency: a review of 330 cases and a proposed follow-up protocol].Semantic proximity Read ↗

Production and Function of Immunoglobulin ASemantic proximity Read ↗

[IgA deficiency].Semantic proximity Read ↗

IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulationSemantic proximity Read ↗

Monogenic mutations associated with IgA deficiency.Semantic proximity Read ↗

Communication between B-Cells and Microbiota for the Maintenance of Intestinal HomeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.