Implication of LRRC4C and DPP6 in neurodevelopmental disorders.

doi:10.1002/ajmg.a.38021

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Article

Implication of LRRC4C and DPP6 in neurodevelopmental disorders.

American journal of medical genetics. Part A - 1 Feb 2017

Maussion Gilles, Cruceanu Cristiana, Rosenfeld Jill A, Bell Scott C, Jollant Fabrice, Szatkiewicz Jin, Collins Ryan L, Hanscom Carrie, Kolobova Ilaria, de Champfleur Nicolas Menjot, Blumenthal Ian, Chiang Colby, Ota Vanessa, Hultman Christina, O'Dushlaine Colm, McCarroll Steve, Alda Martin, Jacquemont Sebastien, Ordulu Zehra, Marshall Christian R, Carter Melissa T, Shaffer Lisa G, Sklar Pamela, Girirajan Santhosh, Morton Cynthia C, Gusella James F, Turecki Gustavo, Stavropoulos Dimitri J, Sullivan Patrick F, Scherer Stephen W, Talkowski Michael E, Ernst Carl

Abstract excerpt

We performed whole-genome sequencing on an individual from a family with variable psychiatric phenotypes that had a sensory processing disorder, apraxia, and autism. The proband harbored a maternally inherited balanced translocation (46,XY,t(11;14)(p12;p12)mat) that disrupted LRRC4C, a member of the highly specialized netrin G family of axon guidance molecules. The proband also inherited a paternally derived...

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PMID: 27759917
DOI: 10.1002/ajmg.a.38021
PMCID: PMC5833302

Genes

DPP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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