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Article

Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot.

International journal of molecular sciences - 13 Oct 2016

Suzuki Hitoshi, Aoki Yoshitsugu, Kameyama Toshiki, Saito Takashi, Masuda Satoru, Tanihata Jun, Nagata Tetsuya, Mayeda Akila, Takeda Shin'ichi, Tsukahara Toshifumi

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a severe muscular disorder. It was reported that multiple exon skipping (MES), targeting exon 45-55 of the DMD gene, might improve patients' symptoms because patients who have a genomic deletion of all these exons showed very mild symptoms. Thus, exon 45-55 skipping treatments for DMD have been proposed as a potential clinical cure. Herein, we detected the expression of...

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Identifiers

PMID: 27754374
DOI: 10.3390/ijms17101722
PMCID: PMC5085753

Genes

DMD

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Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot.PMID 27754374Read ↗

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