Article
Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia.
Leukemia & lymphoma - 1 Jun 2017
De Luca Luciana, D'Arena Giovanni, Simeon Vittorio, Trino Stefania, Laurenzana Ilaria, Caivano Antonella, La Rocca Francesco, Villani Oreste, Mansueto Giovanna, Deaglio Silvia, Innocenti Idanna, Laurenti Luca, Molica Stefano, Pietrantuono Giuseppe, De Stradis Angelo, Del Vecchio Luigi, Musto Pellegrino
Abstract excerpt
Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition,...
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