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Article

Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia.

Metabolic brain disease - 1 Feb 2017

Meyer Meredith, Kovács Attila D, Pearce David A

Abstract excerpt

Infantile CLN1 disease, also known as infantile neuronal ceroid lipofuscinosis, is a fatal childhood neurodegenerative disorder caused by mutations in the CLN1 gene. CLN1 encodes a soluble lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1), and it is still unclear why neurons are selectively vulnerable to the loss of PPT1 enzyme activity in infantile CLN1 disease. To examine the effects of PPT1 deficiency...

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Source

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Identifiers

PMID: 27722792
DOI: 10.1007/s11011-016-9919-6
PMCID: PMC5335868

Genes

PPT1
PDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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