Article
Effectiveness of Elbasvir and Grazoprevir Combination, With or Without Ribavirin, for Treatment-Experienced Patients With Chronic Hepatitis C Infection.
Gastroenterology - 1 Jan 2017
Kwo Paul, Gane Edward J, Peng Cheng-Yuan, Pearlman Brian, Vierling John M, Serfaty Lawrence, Buti Maria, Shafran Stephen, Stryszak Paul, Lin Li, Gress Jacqueline, Black Stuart, Dutko Frank J, Robertson Michael, Wahl Janice, Lupinacci Lisa, Barr Eliav, Haber Barbara
Abstract excerpt
BACKGROUND & AIMS: Patients infected with hepatitis C virus (HCV) genotype 1, 4, or 6, with or without cirrhosis, previously treated with peg-interferon and ribavirin, are a challenge to treat. We performed a phase 3 randomized controlled open-label trial to assess the effects of 12 or 16 weeks of treatment with once-daily elbasvir (an HCV NS5A inhibitor, 50 mg) and grazoprevir (an HCV NS3/4A protease inhibitor,...
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