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Article

Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration

3 Aug 2016

Abstract excerpt

Osteoarthritis (OA) of spine (facet joints [FJs]) is one of the major causes of severe low back pain and disability worldwide. The degeneration of facet cartilage is a hallmark of FJ OA. However, endogenous mechanisms that initiate degeneration of facet cartilage are unknown, and there are no disease-modifying therapies to stop FJ OA. In this study, we have identified microRNAs (small noncoding RNAs) as mediators...

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PMID: 27699225
DOI: 10.1172/jci.insight.86820

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