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Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand

30 Sept 2016

Abstract excerpt

Streptococcus sanguinis is a leading cause of bacterial infective endocarditis, a life-threatening infection of heart valves. S. sanguinis binds to human platelets with high avidity, and this adherence is likely to enhance virulence. Previous studies suggest that a serine-rich repeat adhesin termed SrpA mediates the binding of S. sanguinis to human platelets via its interaction with sialoglycans on the receptor...

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PMID: 27685666
DOI: 10.1021/acs.biochem.6b00704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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