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Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin

2 Feb 2016

Abstract excerpt

Streptococcus sanguinisis a leading cause of infective endocarditis, a life-threatening infection of the cardiovascular system. An important interaction in the pathogenesis of infective endocarditis is attachment of the organisms to host platelets.S. sanguinisexpresses a serine-rich repeat adhesin, SrpA, similar in sequence to platelet-binding adhesins associated with increased virulence in this disease. In this...

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PMID: 26833566
DOI: 10.1074/jbc.m115.701425

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