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Article

Guidelines for Large-Scale Sequence-Based Complex Trait Association Studies: Lessons Learned from the NHLBI Exome Sequencing Project.

American journal of human genetics - 6 Oct 2016

Auer Paul L, Reiner Alex P, Wang Gao, Kang Hyun Min, Abecasis Goncalo R, Altshuler David, Bamshad Michael J, Nickerson Deborah A, Tracy Russell P, Rich Stephen S, Leal Suzanne M

Abstract excerpt

Massively parallel whole-genome sequencing (WGS) data have ushered in a new era in human genetics. These data are now being used to understand the role of rare variants in complex traits and to advance the goals of precision medicine. The technological and computing advances that have enabled us to generate WGS data on thousands of individuals have also outpaced our ability to perform analyses in scientifically...

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Identifiers

PMID: 27666372
DOI: 10.1016/j.ajhg.2016.08.012
PMCID: PMC5065683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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