Article
Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence.
mBio - 20 Sept 2016
Kowalski Caitlin H, Beattie Sarah R, Fuller Kevin K, McGurk Elizabeth A, Tang Yi-Wei, Hohl Tobias M, Obar Joshua J, Cramer Robert A
Abstract excerpt
UNLABELLED: Previous work has shown that environmental and clinical isolates of Aspergillus fumigatus represent a diverse population that occupies a variety of niches, has extensive genetic diversity, and exhibits virulence heterogeneity in a number of animal models of invasive pulmonary aspergillosis (IPA). However, mechanisms explaining differences in virulence among A. fumigatus isolates remain enigmatic....
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