Article
Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients.
Anticancer research - 1 Sept 2016
Kiss Igor, Mlcochova Jitka, Bortlicek Zbynek, Poprach Alexandr, Drabek Jiri, Vychytilova-Faltejskova Petra, Svoboda Marek, Buchler Tomas, Batko Stanislav, Ryska Ales, Hajduch Marian, Slaby Ondrej
Abstract excerpt
BACKGROUND: In metastatic colorectal cancer (mCRC), panitumumab is generally considered to be ineffective after the progression on cetuximab therapy. However, few studies have demonstrated that a small subset of mCRC patients may benefit from panitumumab in this setting. PATIENTS AND METHODS: In our study, wild-type KRAS mCRC patients, enrolled into the nationwide Czech registry CORECT between January 2007 and...
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