Article
Application of mathematical expectation (ME) strategy for detecting low frequency mutations: An example for evaluating 14-bp insertion/deletion (indel) within the bovine PRNP gene.
Prion - 2 Sept 2016
Yang Qing, Zhang Sihuan, Liu Liangliang, Cao Xiukai, Lei Chuzhao, Qi Xinglei, Lin Fengpeng, Qu Weidong, Qi Xingshan, Liu Jiming, Wang Rongmin, Chen Hong, Lan Xianyong
Abstract excerpt
The detection method based on the mathematical expectation (ME) strategy is fast and accuracy for low frequency mutation screening in large samples. Previous studies have found that the 14-bp insertion/deletion (indel) variants of the 3' untranslated region (3' UTR) within bovine PRNP gene have been characterized with low frequency (≤5%) in global breeds outside China, which has not been determined in Chinese...
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