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Article

Novel FOXC2 Mutation in Hereditary Distichiasis Impairs DNA-Binding Activity and Transcriptional Activation.

International journal of biological sciences - 1 Jan 2016

Zhang Leilei, He Jie, Han Bing, Lu Linna, Fan Jiayan, Zhang He, Ge Shengfang, Zhou Yixiong, Jia Renbing, Fan Xianqun

Abstract excerpt

Distichiasis presents as double rows of eyelashes arising from aberrant differentiation of the meibomian glands of the eyelids, and it may be sporadic or hereditary. FOXC2 gene mutations in hereditary distichiasis are rarely reported. Here, we examined two generations of a Chinese family with hereditary distichiasis but without lymphedema or other features of LD syndrome. The FOXC2 gene was amplified and...

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Share to Forkhead Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27570485
DOI: 10.7150/ijbs.13774
PMCID: PMC4997055

Genes

FOXC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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