Article
Combined effects of age and polymorphisms in Notch3 in the pathogenesis of cerebral infarction disease.
Metabolic brain disease - 1 Oct 2016
Zhu Chun-Yu, Wang Yue, Zeng Qing-Xuan, Qian Yu, Li Huan, Yang Zi-Xia, Yang Ya-Mei, Zhang Qiong, Li Fei-Feng, Liu Shu-Lin
Abstract excerpt
Cerebral infarction disease is a severe hypoxic ischemic tissue necrosis in the brain, often leading to long-term functional disability and residual impairments. The Notch signaling pathway plays key roles in proliferation and survival of the stem/progenitor cells of the central and peripheral nervous systems. Notch3 is an important member of the pathway, but the relationships between the genetic abnormalities...
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