Article
Epidermal Growth Factor Receptor Mutation Enhances Expression of Cadherin-5 in Lung Cancer Cells.
PloS one - 1 Jan 2016
Hung Ming-Szu, Chen I-Chuan, Lung Jr-Hau, Lin Paul-Yann, Li Ya-Chin, Tsai Ying-Huang
Abstract excerpt
Epidermal growth factor receptor (EGFR) activation has been shown to play a critical role in tumor angiogenesis. In this study, we investigate the correlation between EGFR mutations and cadherin-5 (CDH5), which is an angiogenic factor, in lung cancer cells. Increased expression CDH5 is observed in lung cancer cells with EGFR mutations. Stable lung cancer cell lines expressing mutant (exon 19 deletion E746-A750,...
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