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Article

Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus.

Infection and immunity - 1 Sept 2016

Loughran Allister J, Gaddy Dana, Beenken Karen E, Meeker Daniel G, Morello Roy, Zhao Haibo, Byrum Stephanie D, Tackett Alan J, Cassat James E, Smeltzer Mark S

Abstract excerpt

We used a murine model of acute, posttraumatic osteomyelitis to evaluate the virulence of two divergent Staphylococcus aureus clinical isolates (the USA300 strain LAC and the USA200 strain UAMS-1) and their isogenic sarA mutants. The results confirmed that both strains caused comparable degrees of osteolysis and reactive new bone formation in the acute phase of osteomyelitis. Conditioned medium (CM) from...

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Identifiers

PMID: 27354444
DOI: 10.1128/IAI.00152-16
PMCID: PMC4995912

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