Assessment and Validation of New Genetic Variants: A Systematic In Silico Approach.

doi:10.1007/978-1-4939-3652-6_2

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Article

Assessment and Validation of New Genetic Variants: A Systematic In Silico Approach.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

García-Berrocal Belén, García-Sánchez Asunción, Isidoro-García María

Abstract excerpt

The application of new high-throughput technologies to the study of asthma and other complex diseases is providing a huge amount of genetic information. Particularly, next-generation sequencing generates thousands of variants that have not been previously related to the studied diseases. These new genetic variants require validation both at methodological and clinical level. In this sense, for methodological...

Topics

Asthma
Computational Biology
Computer Simulation
Electrophoresis, Capillary
Genetic Predisposition to Disease
Genetic Variation
High-Throughput Nucleotide Sequencing
Humans
Sequence Analysis, DNA

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Open in PubMed

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PMID: 27300528
DOI: 10.1007/978-1-4939-3652-6_2

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