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Mitochondrial ND1 Variants in 1281 Chinese Subjects With Leber's Hereditary Optic Neuropathy.

Investigative ophthalmology & visual science - 1 May 2016

Ji Yanchun, Liang Min, Zhang Juanjuan, Zhu Ling, Zhang Zengjun, Fu Runing, Liu Xiaoling, Zhang Minglian, Fu Qun, Zhao Fuxin, Tong Yi, Sun Yanhong, Jiang Pingping, Guan Min-Xin

Abstract excerpt

PURPOSE: The purpose of this study was to investigate the mutational incidence and spectrum of mitochondrial ND1 gene in subjects with Leber's hereditary optic neuropathy (LHON). METHODS: A cohort of 1281 Han Chinese probands and 478 control subjects underwent sequence analysis of mitochondrial (mt)DNA. Resultant variants were evaluated for evolutionary conservation, allelic frequencies, and structural and...

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PMID: 27177320
DOI: 10.1167/iovs.16-19243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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