Article
Impact of whole brain radiation therapy on CSF penetration ability of Icotinib in EGFR-mutated non-small cell lung cancer patients with brain metastases: Results of phase I dose-escalation study.
Lung cancer (Amsterdam, Netherlands) - 1 Jun 2016
Zhou Lin, He Jiazhuo, Xiong Weijie, Liu Yongmei, Xiang Jing, Yu Qin, Liang Maozhi, Zhou Xiaojuan, Ding Zhenyu, Huang Meijuan, Ren Li, Zhu Jiang, Li Lu, Hou Mei, Ding Lieming, Tan Fenlai, Lu You
Abstract excerpt
OBJECTIVES: Whole-brain radiation therapy (WBRT) and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are both treatment options for EGFR-mutated non-small cell lung cancer (NSCLC) patients with brain metastases. However, the dose-escalation toxicity and efficacy of combination therapy, and the effect of WBRT on cerebrospinal fluid (CSF) penetration of EGFR-TKIs are still unclear. MATERIALS...
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