Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improving the Sensitivity and Positive Predictive Value in a Cystic Fibrosis Newborn Screening Program Using a Repeat Immunoreactive Trypsinogen and Genetic Analysis.

The Journal of pediatrics - 1 Aug 2016

Sontag Marci K, Lee Rachel, Wright Daniel, Freedenberg Debra, Sagel Scott D

Abstract excerpt

OBJECTIVE: To evaluate the performance of a new cystic fibrosis (CF) newborn screening algorithm, comprised of immunoreactive trypsinogen (IRT) in first (24-48 hours of life) and second (7-14 days of life) dried blood spot plus DNA on second dried blood spot, over existing algorithms. STUDY DESIGN: A retrospective review of the IRT/IRT/DNA algorithm implemented in Colorado, Wyoming, and Texas. RESULTS: A total of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dried Blood Spot Testing

Share to Neonatal Screening

Share to Predictive Value of Tests

Share to Sensitivity and Specificity

Share to Trypsinogen

Share to United States

Source

Identifiers

PMID: 27131402
DOI: 10.1016/j.jpeds.2016.03.046

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improving the Sensitivity and Positive Predictive Value in a Cystic Fibrosis Newborn Screening Program Using a Repeat Immunoreactive Trypsinogen and Genetic Analysis.PMID 27131402Read ↗

A new cystic fibrosis newborn screening algorithm: IRT/IRT1 upward arrow/DNA.Semantic proximity Read ↗

Screening for cystic fibrosis in New York State: considerations for algorithm improvements.Semantic proximity Read ↗

Newborn Screening for Cystic Fibrosis in California.Semantic proximity Read ↗

Improving outcomes for Colorado's IRT-IRT-DNA cystic fibrosis newborn screening algorithm by implementing floating cutoffs.Semantic proximity Read ↗

Two-tiered immunoreactive trypsinogen-based newborn screening for cystic fibrosis in Colorado: screening efficacy and diagnostic outcomes.Semantic proximity Read ↗

Utility of a very high IRT/No mutation referral category in cystic fibrosis newborn screening.Semantic proximity Read ↗

Cystic fibrosis newborn screening: using experience to optimize the screening algorithm.Semantic proximity Read ↗

Immunoreactive Trypsinogen in Infants Born to Women with Cystic Fibrosis Taking Elexacaftor–Tezacaftor–IvacaftorSemantic proximity Read ↗

Four-year evaluation of neonatal cystic fibrosis screening in Southern Belgium.Semantic proximity Read ↗

The Impact of the CFTR Gene Discovery on Cystic Fibrosis Diagnosis, Counseling, and Preventive Therapy.Semantic proximity Read ↗

Refinement of newborn screening for cystic fibrosis with next generation sequencing.Semantic proximity Read ↗

Neonatal screening for cystic fibrosis using immunoreactive trypsinogen and direct gene analysis: four years' experience.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.