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Article

Evolution of Ceftaroline-Resistant Mrsa in a Child with Cystic Fibrosis Following Repeated Antibiotic Exposure.

The Pediatric infectious disease journal - 1 Jul 2016

Cannavino Christopher R, Mendes Rodrigo E, Sader Helio S, Farrell David J, Critchley Ian A, Biek Donald, Le Jennifer, Skochko Shannon M, Jones Ronald N, Bradley John S

Abstract excerpt

Ceftaroline is the first β-lactam antibiotic with activity against methicillin-resistant Staphylococcus aureus (MRSA). We describe a ceftaroline-resistant MRSA strain, isolated from a girl with cystic fibrosis after 22 ceftaroline treatment courses. MRSA genome sequencing documented a Tyr446Asn alteration in penicillin binding protein 2 that appeared responsible for resistance. Noncompartmental ceftaroline...

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Source

Identifiers

PMID: 27093165
DOI: 10.1097/INF.0000000000001171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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