Article
Ellis Van Creveld2 is Required for Postnatal Craniofacial Bone Development.
Anatomical record (Hoboken, N.J. : 2007) - 1 Aug 2016
Badri Mohammed K, Zhang Honghao, Ohyama Yoshio, Venkitapathi Sundharamani, Kamiya Nobuhiro, Takeda Haruko, Ray Manas, Scott Greg, Tsuji Takehito, Kunieda Tetsuo, Mishina Yuji, Mochida Yoshiyuki
Abstract excerpt
Ellis-van Creveld (EvC) syndrome is a genetic disorder with mutations in either EVC or EVC2 gene. Previous case studies reported that EvC patients underwent orthodontic treatment, suggesting the presence of craniofacial bone phenotypes. To investigate whether a mutation in EVC2 gene causes a craniofacial bone phenotype, Evc2 knockout (KO) mice were generated and cephalometric analysis was performed. The heads of...
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