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Article

Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome

18 Apr 2016

Abstract excerpt

There is mounting evidence that the microbiome has potent immunoregulatory functions. We assessed the effects of intestinal dysbiosis in a model of Sjögren syndrome (SS) by subjecting mice to desiccating stress (DS) and antibiotics (ABX). We characterized the conjunctival, tongue and fecal microbiome profiles of patients with SS. Severity of ocular surface and systemic disease was graded. 16S ribosomal RNA gene...

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PMID: 27087247
DOI: 10.1038/srep23561

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