Article
CHCHD10 is not a frequent causative gene in Chinese ALS patients.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Jan 2000
Li Xiao Ling, Shu Shi, Li Xiao Guang, Liu Qing, Liu Fang, Cui Bo, Liu Ming Sheng, Peng Bin, Cui Li Ying, Zhang Xue
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the death of motor neurons. Recently, mutations in CHCHD10 have been reported to cause ALS in Western populations. In the present study, direct DNA sequencing has been performed on CHCHD10 in a cohort of 294 ALS patients of Chinese Han origin. No mutations were identified in CHCHD10 in ALS cases of Chinese ancestry....
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