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Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

12 Apr 2016

Abstract excerpt

Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant...

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PMID: 27071553
DOI: 10.1186/s12967-016-0843-7

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