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Article

HIV Drug to Aid Melanoma Therapies?

Cancer cell - 14 Mar 2016

Kim Hyungsoo, Ronai Ze'ev A

Abstract excerpt

The HIV1 protease inhibitor nelfinavir is being investigated as a cancer therapeutic. In this issue of Cancer Cell, Smith et al. (2016) report that nelfinavir suppresses MITF expression induced by MAPK pathway inhibition in melanoma cells and sensitizes melanoma cells with NRAS or BRAF plus NRAS mutations to MEK inhibitors.

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Topics

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Source

Identifiers

PMID: 26977874
DOI: 10.1016/j.ccell.2016.02.014

Genes

NRAS
BRAF
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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