Do incident and recurrent venous thromboembolism risks truly differ between heterozygous and homozygous Factor V Leiden carriers? A retrospective cohort study.

doi:10.1016/j.ejim.2016.02.023

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Article

Do incident and recurrent venous thromboembolism risks truly differ between heterozygous and homozygous Factor V Leiden carriers? A retrospective cohort study.

European journal of internal medicine - 1 May 2016

Perez Botero J, Ormsby W D, Ashrani A A, McBane R D, Wysokinski W E, Patnaik M M, Lewis B R, Grill D E, Pruthi R K, Heit J A

Abstract excerpt

INTRODUCTION: While Factor V Leiden (F5 rs6025 A allele) is a known venous thromboembolism (VTE) risk factor, VTE risk among heterozygous vs. homozygous carriers is uncertain. MATERIALS AND METHODS: In a retrospective cohort study of Mayo Clinic patients referred for genotyping between 1996 and 2013, we tested Factor V Leiden genotype as a risk factor for incident and recurrent VTE. RESULTS: Among heterozygous...

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PMID: 26970916
DOI: 10.1016/j.ejim.2016.02.023

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