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Programming of maternal and offspring disease: impact of growth restriction, fetal sex and transmission across generations

12 Mar 2016

Abstract excerpt

Babies born small are at an increased risk of developing myriad adult diseases. While growth restriction increases disease risk in all individuals, often a second hit is required to unmask 'programmed' impairments in physiology. Programmed disease outcomes are demonstrated more commonly in male offspring compared with females, with these sex-specific outcomes partly attributed to different placenta-regulated...

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PMID: 26970222
DOI: 10.1113/jp271745

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