Article
[Epigenetics and Life-style diseases].
Clinical calcium - 1 Mar 2016
Waki Hironori, Yamauchi Toshimasa, Kadowaki Takashi
Abstract excerpt
Genomic DNA in eukaryotes forms a highly-organized structure called chromatin. Epigenetic regulation of genes involves DNA methylation and modifications of the histone tails such as acetylation and methylation, which lead to a given phenotype without a change in nucleotide sequence. Both genetic and environmental factors play important roles in the development of life-style diseases. Epigenetic regulation is...
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