Article
Trophoblast Retrieval and Isolation From the Cervix for Noninvasive, First Trimester, Fetal Gender Determination in a Carrier of Congenital Adrenal Hyperplasia.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Jun 2016
Bolnick Alan D, Fritz Rani, Jain Chandni, Kadam Leena, Bolnick Jay M, Kilburn Brian A, Singh Manvinder, Diamond Michael P, Drewlo Sascha, Armant D Randall
Abstract excerpt
Congenital adrenal hyperplasia (CAH) is an autosomal recessive defect in cortisol biosynthesis that elevates fetal androgen levels to cause genital ambiguity and external genital masculinization in newborn females. Introducing dexamethasone in utero by 7 weeks gestation precludes virilization of affected females. However, identification of a male fetus prior to week 7 could avert the necessity of steroid...
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