Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial.

doi:10.1016/S1473-3099(16)00052-9

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Article

Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial.

The Lancet. Infectious diseases - 1 Jun 2016

Manns Michael, Samuel Didier, Gane Edward J, Mutimer David, McCaughan Geoff, Buti Maria, Prieto Martín, Calleja José Luis, Peck-Radosavljevic Markus, Müllhaupt Beat, Agarwal Kosh, Angus Peter, Yoshida Eric M, Colombo Massimo, Rizzetto Mario, Dvory-Sobol Hadas, Denning Jill, Arterburn Sarah, Pang Phillip S, Brainard Diana, McHutchison John G, Dufour Jean-François, Van Vlierberghe Hans, van Hoek Bart, Forns Xavier

Abstract excerpt

BACKGROUND: Treatment options are limited for patients infected by hepatitis C virus (HCV) with advanced liver disease. We assessed the safety and efficacy of ledipasvir, sofosbuvir, and ribavirin in patients with HCV genotype 1 or 4 and advanced liver disease. METHODS: We did an open-label study at 34 sites in Europe, Canada, Australia, and New Zealand. Cohort A included patients with Child-Turcotte-Pugh class B...

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PMID: 26907736
DOI: 10.1016/S1473-3099(16)00052-9

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