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Article

Apparent mineralocorticoid excess and the long term treatment of genetic hypertension.

The Journal of steroid biochemistry and molecular biology - 1 Jan 2017

Razzaghy-Azar Maryam, Yau Mabel, Khattab Ahmed, New Maria I

Abstract excerpt

Apparent mineralocorticoid excess (AME) is a genetic disorder causing severe hypertension, hypokalemia, and hyporeninemic hypoaldosteronism owing to deficient 11 beta-hydroxysteroid dehydrogenase type-2 (11βHSD2) enzyme activity. The 11βHSD2 enzyme confers mineralocorticoid receptor specificity for aldosterone by converting cortisol to its inactive metabolite, cortisone and inactivating the...

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Identifiers

PMID: 26892095
DOI: 10.1016/j.jsbmb.2016.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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