Article
Occurrence of phaeochromocytoma tumours in RET mutation carriers - a single-centre study.
Endokrynologia Polska - 1 Jan 2016
Kotecka-Blicharz Agnieszka, Hasse-Lazar Kornelia, Jurecka-Lubieniecka Beata, Pawlaczek Agnieszka, Oczko-Wojciechowska Małgorzata, Bugajska Beata, Ledwon Aleksandra, Król Aleksandra, Michalik Barbara, Jarząb Barbara
Abstract excerpt
INTRODUCTION: Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant genetic syndrome caused by germline mutation in RET proto-oncogene. The most common mutations are in a cysteine rich domain. Phaeochromocytoma will develop in approximately 50% of RET proto-oncogene carriers. MATERIAL AND METHODS: The studied population consisted of 228 RET proto-oncogene mutation carriers. Monitoring for the...
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