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Article

Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma.

Journal of neuropathology and experimental neurology - 1 Mar 2016

Kristensen Lasse S, Michaelsen Signe R, Dyrbye Henrik, Aslan Derya, Grunnet Kirsten, Christensen Ib J, Poulsen Hans S, Grønbæk Kirsten, Broholm Helle

Abstract excerpt

Methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is a predictive and prognostic marker in newly diagnosed glioblastoma patients treated with temozolomide but how MGMT methylation should be assessed to ensure optimal detection accuracy is debated. We developed a novel quantitative methylation-specific PCR (qMSP) MGMT assay capable of providing allelic methylation data and analyzed 151...

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Source

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Identifiers

PMID: 26883115
DOI: 10.1093/jnen/nlv024
PMCID: PMC4777218

Genes

MGMT

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