Article
Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures.
Scientific reports - 29 Jan 2016
Desmarets Lowiese M B, Vermeulen Ben L, Theuns Sebastiaan, Conceição-Neto Nádia, Zeller Mark, Roukaerts Inge D M, Acar Delphine D, Olyslaegers Dominique A J, Van Ranst Marc, Matthijnssens Jelle, Nauwynck Hans J
Abstract excerpt
Feline infectious peritonitis (FIP) results from mutations in the viral genome during a common feline enteric coronavirus (FECV) infection. Since many virological and immunological data on FECV infections are lacking, the present study investigated these missing links during experimental infection of three SPF cats with FECV strain UCD. Two cats showed mild clinical signs, faecal shedding of infectious virus from...
Topics
- Animals
- Antibodies, Neutralizing
- Antibodies, Viral
- Cats
- Cells, Cultured
- Coronavirus, Feline
- Enterocytes
- Evolution, Molecular
- Feces
- Feline Infectious Peritonitis