Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes.

doi:10.1186/s12933-016-0339-z

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Evidence of a causal relationship between high serum adiponectin levels and increased cardiovascular mortality rate in patients with type 2 diabetes.

Cardiovascular diabetology - 27 Jan 2016

Ortega Moreno Lorena, Copetti Massimiliano, Fontana Andrea, De Bonis Concetta, Salvemini Lucia, Trischitta Vincenzo, Menzaghi Claudia

Abstract excerpt

BACKGROUND: Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been repeatedly reported as an independent positive predictor of cardiovascular mortality. METHODS: A Mendelian randomization approach was used, in order to evaluate whether such counterintuitive association recognizes a cause-effect relationship. To this purpose, single nucleotide polymorphism rs822354 in the...

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PMID: 26817832
DOI: 10.1186/s12933-016-0339-z
PMCID: PMC4730617

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ADIPOQ

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