Article
Upregulation of the double-stranded RNA binding protein DGCR8 in invasive ductal breast carcinoma.
Gene - 1 May 2016
Fardmanesh Hedieh, Shekari Mohammad, Movafagh Abolfazl, Alizadeh Shargh Shohreh, Poursadegh Zonouzi Ali Akbar, Shakerizadeh Samira, Poursadegh Zonouzi Ahmad, Hosseinzadeh Asghar
Abstract excerpt
High-throughput experimental studies have indicated that the miRNAome is globally downregulated in various types of malignancy, and dysregulation of miRNAs processing component(s) is one possible mechanism for this phenomenon. Despite the progression in identifying cellular functions of Digeorge Syndrome Critical Region 8 (DGCR8) in miRNAs biogenesis, the role of altered expression of DGCR8 in the pathogenesis of...
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