Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biallelic FANCD1/BRCA2 mutations predisposing to glioblastoma multiforme with multiple oncogenic amplifications.

Cancer genetics - 1 Jan 2000

Dodgshun Andrew J, Sexton-Oates Alexandra, Saffery Richard, Sullivan Michael J

Abstract excerpt

Fanconi anaemia (FA) caused by biallelic mutation in FANCD1/BRCA2 is rare but carries a high risk of early onset cancer. Medulloblastoma is well described in this cohort but reports of other brain tumours are uncommon. The molecular profile of tumours from FA patients is not well reported. A glioblastoma multiforme (GBM) from a 3-year-old patient with FA and confirmed biallelic BRCA2 mutations was submitted for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to BRCA2 Protein
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to MDM4 gene

Share to Genes, BRCA2

Share to Glioblastoma

Share to Mutation

Source

Identifiers

PMID: 26740091
DOI: 10.1016/j.cancergen.2015.11.005

Genes

BRCA2
CDK6
MDM4
MET
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biallelic FANCD1/BRCA2 mutations predisposing to glioblastoma multiforme with multiple oncogenic amplifications.PMID 26740091Read ↗

Fanconi anemia and biallelic BRCA2 mutation diagnosed in a young child with an embryonal CNS tumor.Semantic proximity Read ↗

Fanconi Anaemia, Childhood Cancer and the BRCA Genes.Semantic proximity Read ↗

Fanconi anemia with biallelic FANCD1/BRCA2 mutations - Case report of a family with three affected children.Semantic proximity Read ↗

The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations.Semantic proximity Read ↗

Biallelic BRCA2 mutations are associated with multiple malignancies in childhood including familial Wilms tumour.Semantic proximity Read ↗

NF1 glioblastoma clonal profiling reveals KMT2B mutations as potential somatic oncogenic events.Semantic proximity Read ↗

Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2.Semantic proximity Read ↗

A novel cancer risk prediction score for the natural course of FA patients with biallelic BRCA2/FANCD1 mutations.Semantic proximity Read ↗

Fanconi anaemia, BRCA2 mutations and childhood cancer: a developmental perspective from clinical and epidemiological observations with implications for genetic counselling.Semantic proximity Read ↗

Genotype-cancer association in patients with Fanconi anemia due to pathogenic variants in FANCD1 (BRCA2) or FANCN (PALB2).Semantic proximity Read ↗

Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia.Semantic proximity Read ↗

Diverse molecular pattern in a bihemispheric glioblastoma (butterfly glioma) in a 16-year-old boy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.