Assessing the role of TUBA4A gene in frontotemporal degeneration.

doi:10.1016/j.neurobiolaging.2015.10.030

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Article

Assessing the role of TUBA4A gene in frontotemporal degeneration.

Neurobiology of aging - 1 Feb 2016

Dols-Icardo Oriol, Iborra Oriol, Valdivia Jessica, Pastor Pau, Ruiz Agustín, López de Munain Adolfo, Sánchez-Valle Raquel, Álvarez Victoria, Sánchez-Juan Pascual, Lleó Alberto, Fortea Juan, Blesa Rafael, Cardona Fernando, Baquero Miquel, Alonso María Dolores, Ortega-Cubero Sara, Pastor María A, Razquin Cristina, Boada Mercè, Hernández Isabel, Gorostidi Ana, Moreno Fermín, Zulaika Miren, Lladó Albert, Coto Eliecer, Combarros Onofre, Pérez-Tur Jordi, Clarimón Jordi

Abstract excerpt

The tubulin alpha 4a (TUBA4A) gene has been recently associated with amyotrophic lateral sclerosis. Interestingly, some of the mutation carriers were also diagnosed with frontotemporal degeneration (FTD) or mild cognitive impairment. With the aim to investigate the role of TUBA4A in FTD, we screened TUBA4A in a series of 814 FTD patients from Spain. Our data did not disclose any nonsense or missense variant in...

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PMID: 26675813
DOI: 10.1016/j.neurobiolaging.2015.10.030

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