Article
TUBA4A may not be a significant genetic factor in Chinese ALS patients.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Jan 2015
Li Jiao, He Ji, Tang Lu, Chen Lu, Xu Lianping, Ma Yan, Zhang Nan, Fan Dongsheng
Abstract excerpt
TUBA4A gene has recently been identified as a potential candidate amyotrophic lateral sclerosis(ALS)-associated gene using exome-wide rare variant burden analysis. The identification of novel TUBA4A variants in Italian ALS patients further support the role of TUBA4A in ALS. We sequenced the coding region of exon 4 in the TUBA4A gene in a cohort consisting of 80 familial ALS probands, 500 sporadic ALS patients and...
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