[Association between VAPB mutations and familial amyotrophic lateral sclerosis in Chinese patients].

Abstract excerpt

OBJECTIVE: To explore the mutations of VAPB (vesicle associated membrane protein/synaptobrevin associated membrane protein B) in Chinese patients with familial amyotrophic lateral sclerosis (FALS). METHODS: The clinical data were collected from 40 FALS families from 2008 to 2011 and the mutations of VAPB gene screened in probands using polymerase chain reaction (PCR) and direct sequencing. RESULTS: All 40 ALS...

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