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Article

Reevaluation of the role of Pex1 and dynamin-related proteins in peroxisome membrane biogenesis.

The Journal of cell biology - 7 Dec 2015

Motley Alison M, Galvin Paul C, Ekal Lakhan, Nuttall James M, Hettema Ewald H

Abstract excerpt

A recent model for peroxisome biogenesis postulates that peroxisomes form de novo continuously in wild-type cells by heterotypic fusion of endoplasmic reticulum-derived vesicles containing distinct sets of peroxisomal membrane proteins. This model proposes a role in vesicle fusion for the Pex1/Pex6 complex, which has an established role in matrix protein import. The growth and division model proposes that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26644516
DOI: 10.1083/jcb.201412066
PMCID: PMC4674274

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