Article
Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations.
Circulation journal : official journal of the Japanese Circulation Society - 1 Jan 2016
Tada Hayato, Kawashiri Masa-Aki, Yoshida Taiji, Teramoto Ryota, Nohara Atsushi, Konno Tetsuo, Inazu Akihiro, Mabuchi Hiroshi, Yamagishi Masakazu, Hayashi Kenshi
Abstract excerpt
BACKGROUND: It has been shown that serum lipoprotein(a) [Lp(a)] is elevated in familial hypercholesterolemia (FH) with mutation(s) of the LDL receptor (LDLR) gene. However, few data exist regarding Lp(a) levels in FH with gain-of-function mutations of the PCSK9 gene. METHODS AND RESULTS: We evaluated 42 mutation-determined heterozygous FH patients with aPCSK9gain-of-function mutation (FH-PCSK9, mean age 52, mean...
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