Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum.

doi:10.1016/j.ebiom.2015.08.018

Back to search

Article

Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum.

EBioMedicine - 1 Oct 2015

Devereux Graham, Fraser-Pitt Douglas, Robertson Jennifer, Devlin Edward, Mercer Derry, O'Neil Deborah

Abstract excerpt

BACKGROUND: Cysteamine has recently been shown to have in vitro properties potentially therapeutically beneficial in cystic fibrosis (CF). In this study we investigated the antimicrobial and mucolytic activity of cysteamine against the complex biologic matrix of CF sputum. METHODS: Sputum samples were obtained from 23 CF adults. Sputum polymicrobial content after in vitro exposure to cysteamine and standard CF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Microbial Sensitivity Tests

Share to Nontuberculous Mycobacteria

Share to Opportunistic Infections

Share to Sputum

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Cysteamine as a Future Intervention in Cystic Fibrosis Against Current and Emerging Pathogens: A Patient-based ex vivo Study Confirming its Antimicrobial and Mucoactive Potential in Sputum.PMID 26629546Read

Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutationSemantic proximity Read

Towards a rational combination therapy of cystic fibrosis: How cystamine restores the stability of mutant CFTR.Semantic proximity Read

Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.Semantic proximity Read

Hypertonic saline in treatment of pulmonary disease in cystic fibrosis.Semantic proximity Read

Inhalable nano into micro dry powders for ivacaftor delivery: The role of mannitol and cysteamine as mucus-active agents.Semantic proximity Read

Cyanide levels found in infected cystic fibrosis sputum inhibit airway ciliary functionSemantic proximity Read

Emerging drugs for cystic fibrosisSemantic proximity Read

Cystic Fibrosis: A Review.Semantic proximity Read