Article
Clarithromycin Resistance Mutations in Helicobacter pylori in Association with Virulence Factors and Antibiotic Susceptibility of the Strains.
Microbial drug resistance (Larchmont, N.Y.) - 1 Apr 2016
Boyanova Lyudmila, Markovska Rumyana, Yordanov Daniel, Gergova Galina, Mitov Ivan
Abstract excerpt
Antibiotic resistance is the major cause for Helicobacter pylori eradication failure. H. pylori clarithromycin resistance mutations were evaluated in 84 (82 phenotypically clarithromycin resistant and 2 intermediately susceptible) strains by allele-specific PCR and 3'-mismatched PCR. Many (57.1%) of these strains were metronidazole resistant. Prevalence of cagA(+), cagE(+), vacA s1a, m1, i1, and i2 strains was...
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